Cryoprecipitate

American Red Cross Cryoprecipitated AHF (Cryo)

In February 2022, the Red Cross obtained licensure of cryoprecipitated AHF (Cryo) prepared from plasma frozen within 24 hours, allowing for a more secure supply. Both single and Cryo pools are available.

Cryo Products

Cryoprecipitated AHF is an acellular blood component used for fibrinogen supplementation, particularly for hypofibrinogenemia fibrinogen, anemia associated with bleeding or congenital deficiency. Cryo is also enriched for coagulation factors 8 and 13 and von Willebrand factor.

Product Specifications

Single

Cryo contains fibrinogen, Factor VIII, Factor XIII, von Willebrand Factor (vWF), and fibronectin. Each unit of Cryo contains an average of 215 IU of Factor VIII and 700 mg of fibrinogen. The average volume is 24mL with the typical range between 20-25mL
Cryo is prepared by thawing one (1) unit of plasma at 1–6°C and recovering the cold insoluble precipitate which is refrozen within one hour.

Pooled

Pooled Cryo contains an average of 750 IU of Factor VIII and 3000 mg of fibrinogen. The average pool volume is 100ml with the typical range between 80-115 mL. The volume of the product is indicated on the label.
Pooled Cryo contains five (5) ABO identical single Cryo units.
CMV testing and leukoreduction are not required.

Shelf life of single and pooled Cryo is one (1) year; once thawed it should be transfused within six hours. Thawed Cryo is stored at room temperature <6 hours.